Christophe E. Pierreux

ROLE
Group Leader, Cell Unit

DEPARTMENT
Epithelial Differentiation And Endocytic Homeostasis

ROLE IN THE CONSORTIUM

DDI will be in charge of the characterization of the 3D organization of the developing pancreatic endothelial compartment and of its transcriptome. In addition, we will evaluate the relative abundance of the three main pancreatic cell types and participate in the integration of the vasculature in the bioprinted constructs.

QUALIFICATIONS

Developmental and cell biologist

CORE EXPERTISE

Pancreas
Endothelium
Morphogenesis
Paracrine communication

Publications

[Full PubMed List]

‘Single cell transcriptomic comparison between mouse embryonic pancreas and pancreatic organoids generated from mouse embryonic stem cell-derived mesoderm and pancreatic progenitors.’ Shlomit Edri, Vardit Rosenthal, Or Ginsburg, Abigail Newman Frisch, Christophe E. Pierreux, Nadav Sharon, Shulamit Levenberg. BioRxiv. 2022: doi: https://doi.org/10.1101/2022.10.11.511696 [DOI]
‘Identification of tissue-enriched ligands and implication in epithelial-endothelial crosstalk during pancreas development.’ Moulis M, Runser S, Glorieux L, Dauguet N, Vanderaa C, Gatto L, Spagnoli F, Iber D, Pierreux CE. Scientific Reports. 2022 [Nature]
‘Extracellular vesicles produced by endothelial progenitor cells promote thyroid follicle formation.’ Degosserie J, Heymans C, Spourquet C, Halbout M, Van Der Smissen P, Vertommen D, Courtoy PJ, Tyteca D, Pierreux CE. J Extracell Vesicles. 2018; 7:1487250. PMID: 29963298 [PubMed]
‘Bioprinting of functional and vascularized mouse thyroid gland construct.’ Bulanova EA, Koudan EV, Degosserie J, Heymans C, Pereira FD, Parfenov VA, Sun Yi, Wang Qi, Akhmedova SA, Sergeeva NS, Frank GA, Khesuani YD, Pierreux CE, Mironov VA. Biofabrication. 2017; 9:034105. PMID: 28707625 [PubMed]
‘Thyroid follicle development requires Smad1/Smad5- and endothelial-dependent basement membrane assembly.’ Villacorte M, Delmarcelle AS, Lernoux M, Bouquet M, Lemoine P, Bolsée J, Umans L, de Sousa Lopes SC, Van Der Smissen P, Sasaki T, Bommer G, Henriet P, Refetoff S, Lemaigre FP, Zwijsen A, Courtoy PJ, Pierreux CE. Development. 2016; 143:1958-70. PMID: 27068110 [PubMed]
‘Reciprocal epithelial: endothelial paracrine interactions during thyroid development govern follicular organization and C-cells differentiation.’ Hick AC, Delmarcelle AS, Bouquet M, Klotz S, Copetti T, Forez C, Van Der Smissen P, Sonveaux P, Feron O, Courtoy PJ, Pierreux CE. Dev Biol. 2013 ; 381:227-40. PMID: 23707896 [PubMed]
‘Epithelial: Endothelial cross-talk regulates exocrine differentiation in developing pancreas.’ Pierreux CE, Cordi S, Hick AC, Achouri Y, Ruiz de Almodovar C, Prévot PP, Courtoy PJ, Carmeliet P, Lemaigre FP. Dev Biol. 2010 ; 347:216-27. PMID: 20807526 [PubMed]